Not much method to this madness. I'll only talk about the good ones.
*NOTE: Some are found in Gifts that you only get if you're saving Little
Sisters.*
Physical Tonics
Hacker's Delight 1 - In the Pavilion, the first one of the game. You get
health for hacking, but you will only hack a lot if you're aiming for
that achievement. Otherwise, skip this.
Hacker's Delight 2 - Invent. Eh, use if you got nothing else I guess.
Hacker's Delight 3 - In the room with the helmets in Prometheus. By this
point, there is no point to using this thing.
EVE Link 1 - First Garden. You get some EVE for each med kit used. Okay.
EVE Link 2 - Near the U-Invent in the Market. More EVE for each med kit.
Pretty good, especially if you use lots of plasmids.
Medical Expert 1 - In the Bounty. Adds more bang to your med kits. This
line of tonics is great, so keep replacing as you get them.
Medical Expert 2 - Beat Frolic and Cohen rewards you with this one. Upgrade to
this one.
Medical Expert 3 - In the poor house in Apollo. Upgrade to this baby for mucho
health.
Security Evasion 1 - In the grotto of Arcadia, after the poison. Stalls the
alarms from cameras. No use, unless you're just going Rambo and running
into places without looking for cameras.
Security Evasion 2 - In the Heat Loss room of Hephaestus. Again, just play
smart and you don't need this.
Extra Nutrition 1 - Garden in the Bounty. I like this one because it turns
all those tiny health boosters into decent health boosters. There will
be snacks and bandages throughout the game, so I like this one.
Extra Nutrition 2 - In the basement of the Plaza in Frolic (remember to use
that hidden button in Sinclair). I like this one a lot.
Extra Nutrition 3 - Research Spider Splicers. Again, replace the last one with
this one, but you SHOULD get this one before #2, so I would equip this
one ASAP.
Booze Hound - Invent. Make beer your friend! It's a good one if you don't
have another better one. I like it though.
Bloodlust - Invent. Get health and EVE from wrench hits. Again, I don't go
down the wrench road, so I don't use this stuff.
Natural Camouflage - Research Houdinis. The best tonic in the game, no doubt.
Equip so that you can hide when you need to, but you can't hide from
enemies that have already found you.
Scrounger - Research Leadhead Splicers. Another one of those must haves, and
you can get it early in the game. Awesome to get better items from
your loot. If you don't like what something is giving you, just press
RT and get possibly better items (great for getting enzymes).
SportBoost 1 - Research Thuggish Splicers. ONLY good for wrench users. It's
great if you do, but useless otherwise.
SportBoost 2 - Research Thuggish Splicers. Same as above.
Engineering Tonics
Security Expert 1 - In the Pavilion. Helps hacking machines, so use until you
find better stuff.
Security Expert 2 - Research Security Bot. No, you should not need either of
these by the time you find this one.
Hacking Expert 1 - In the LangFord labs. One less overload and one less alarm
tile.
Hacking Expert 2 - Garden in Fort Frolic. Two less of each.
Focused Hacker 1 - In the Fisheries of the Bounty. Two less overload tiles.
Focused Hacker 2 - In the poor house in Apollo. Four less overload tiles.
Alarm Expert 1 - Jump to the balcony in the theatre of Frolic. Two less alarm
tiles during the hack game.
Alarm Expert 2 - In the voice room of the Eugenics area. Four less alarm
tiles.
Shorten Alarms 1 - Garden in Arcadia. Only if you don't know where the cameras
are in the game and you get caught a lot. But no, don't use this at
all.
Shorten Alarms 2 - In Geothermal room of Hephaestus. Nah, no use.
Speedy Hacker 1 - In the Dental area of Pavilion. Slows the flow of the goo
during the hack game. Pretty good, early on. By the late game you
should be constantly be capped off on hack tools and your research in
the machines will help you hack them easy. Not to mention you can just
buyout machines. But it's still a good early choice.
Speedy Hacker 2 - Olympus Heights's Garden. Replace the other one with this
one if you must.
Clever Inventor - In Suchong's room of Olympus. One less component for
inventing stuff.
Prolific Inventor - Gift near Garden of Apollo. Double what you get from
inventing. A must if you're going for 100 invented items.
Safecracker 1 - In a Gift in Arcadia. Eh, not enough safes and I would advise
using hack tools on safes anyway.
Safecracker 2 - In the Little Wonders place in Prometheus. No, don't use it.
Combat Tonics
Static Discharge 1 - In the hall before you meet Dr. Steinman. This is by far
the best combat tonic. Put it on and you will punish enemies that
hit you.
Static Discharge 2 - Research Leadhead Splicers. Combine with the last one
for added bang.
Wrench Jockey 1 - In the Dental area of the Pavilion. Better wrench damage.
Wrench Jockey 2 - Research Bouncers. Eh, unless you already use the wrench,
skip em both.
Wrench Lurker 1 - In the tavern of the Bounty. Only good if you want to sneak
around and get stealth kills. Since sneaking is slow, don't bother.
Wrench Lurker 2 - Garden of Hephaestus Core. Skip like the last one.
Photographer's Eye 1 - In Worley Winery of Farmer's Market. Great for adding
more research to every photo.
Photographer's Eye 2 - Research Rosies. You can get this one before you get
the first one, which is what I did.
Frozen Field 1 - In the Frozen Tunnel of Frolic. Eh, not any good unless you're
already choosing the wrench tonics. Just skip if you prefer guns.
Frozen Field 2 - Hephaestus.
Armored Shell 1 - First Garden. Lowers damage you take.
Armored Shell 2 - Gift in Olympus Heights.
Human Inferno 1 - G. Garden in Arcadia. Good for using your fire damage, but
it's not worth it in the long run.
Human Inferno 2 - Garden in Prometheus.
Damage Research 1 - In the Workshops of Hephaestus. Adds bang to your research
bonuses.
Damage Research 2 - In the Mendel Library in Prometheus.
Electric Flesh 1 - Cohen's room in the theatre of Fort Frolic. Decent on it's
own, but I would skip it.
Electric Flesh 2 - Fontaine's room in Olympus.
Research Tonics
Listed elsewhere, but here are what you gain from snapping photos of these
enemies.
*It goes: [Splicer] - [Tonic name]. Type.*
Leadhead - Scrounger. Physical Tonic.
Leadhead - Static Discharge 2. Combat Tonic.
Houdini - Natural Camouflage. Combat Tonic.
Thuggish - SportBoost. Physical Tonic.
Rosie - Photographer's Eye 2. Combat Tonic.
Spider - Extra Nutrition 3. Physical Tonic.
Thuggish - SportBoost 2. Physical Tonic.
Security Bot - Security Expert 2. Engineering Tonic.
Bouncer - Wrench Jockey 2. Combat Tonic.
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